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Protein S, Total Antigen
Ordering Recommendation
Not recommended for detecting protein S deficiency; preferred test is Protein S Free, Antigen (0098894). Use to subtype deficiency in known protein S-deficient individuals in combination with Protein S Free, Antigen (0098894), or Protein S, Functional (0030114). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
New York DOH Approval Status
Specimen Required
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum. EDTA plasma, clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months
Methodology
Microlatex Particle-Mediated Immunoassay
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
| Age | Male | Female |
|---|---|---|
| 1-4 days | 12-60% | 12-60% |
| 5-29 days | 22-78% | 22-78% |
| 30-89 days | 33-93% | 33-93% |
| 90-179 days | 54-118% | 54-118% |
| 180-364 days | 55-119% | 55-119% |
| 1-5 years | 54-118% | 54-118% |
| 6-10 years | 41-114% | 41-114% |
| 11 years and older | 84-134% | 63-126% |
Interpretive Data
Patients on warfarin may have decreased protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein S.
FDA
Note
Hotline History
CPT Codes
85305
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0030112 | Protein S, Total Antigen | 27823-4 |
Aliases
- Free Protein S Antigen
- Protein S Antigen, S Protein Antigen
- Total Protein S Antigen
